- wenqiang.chen@joslin.harvard.edu
- wenqiang.chen.01@regionh.dk
Unpublished works
(Sneek Peak)
Here I am presenting a sneek peak of some of my unpublished works
The sooner data is shared, the sooner others can build on it"
(Founding Editor-in-Chief of PLOS Computational Biology)
- Also driven by the concept of open science, I am committed to earlier sharing of thoughts and ideas even before they are formally submitted and accepted.
- That’s why I am dedicated to share unpublished data in my invited talks or oral presentations.
- Here I create a section to update my currently unpublished work, which will include:
- works in press (as long as being published online, they will be moved to the Publications section).
- works in preparation (I will share my thoughs on outline of the figures, or even some interesting findings)
- on-going projects (although they might be too preliminary, I would share the status of these projects and the expected delivery timeline for writing or submission)
- Through these efforts, I hope to receive early inputs and early sharing of knowledge.
(1) Microglia IR/IGF1R signaling in AD pathogenesis
*NOTE: My current MG-IRKO work is in submission, but below this is a project dedicated to the double knockout of insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) from microglia cells.
Status:
- mouse strain established,
- tissues/samples harvested,
- data collection completed,
- initial figure organization completed.,
- manuscript writing, however, not finished yet.
Aims:
- dissecting microglia IR and/or IGF1R signalings in health and in diseases
- compare microglia IR signaling and IGF1R signaling during AD pathogenesis
Approaches:
- conditional KO mouse strains,
- MG-IRKO
- MG-IGF1RKO
- MG-DKO
- cross these cKO mouse strains with RiboTag mouse strain to create the following 3 new strains
- MG-IRKO/RiboTag
- MG-IGF1RKO/RiboTag
- MG-DKO/RiboTag
- cross these cKO mouse strains with 5xFAD AD mouse line to create the following 3 new strains
- MG-IRKO/5xFAD
- MG-IGF1RKO/5xFAD
- MG-DKO/5xFAD
(2) Spotlight: Trends in Biochemical Sciences
BVR-A (Writting done, to be submitted)
This is a commentatory paper to Dr. Eugenio Barone’s recently published paper on Redox Biology.
- we discuss the importance and implication of the BVR-A-mediated brain insulin resistance in the pathogenesis of T2D and AD.
- we have got the invitation from TIBS to submit.
- Now the paper is in the senior PI to review and will be sent to TIBS before September 20.
(3) mini-review: Trends in Endocrinology and Metabolism
Hormone of the Month, Insulin (Minor Review, revised)
This is another mini-review series that I just finished writing and will be submitting to the TEM.
- I summarized insulin’s secretion and physiological functions
- I also discussed insulin’s main role in glucose metabolism and highlighted insulin signaling pathways
This mini-review was commissioned by the TEM editor and has completed the first-round peer review (minor revision).
(4) To be continued
Example images
© 2024 All Rights Reserved.
Share:
More Posts
Global Collboration with Young PIs
Global Collaborationwith Young PIs My general statement: Do something, not be someone. Wenqiang Chen, Ph.D. As a young investigator in the field of neuroscience, I
Leadership
Leadership My general statement: Do something, not be someone. Wenqiang Chen, Ph.D. To me, leadership is one of the most essential qualities in any profession.
Mentorship – my Mentees
wenqiang.chen@joslin.harvard.edu wenqiang.chen.01@regionh.dk Teaching & my mentees My general statements: “Having been shaped by incredible mentors, I am committed to paying it forward. My goal is
Mentorship – my Mentors
wenqiang.chen@joslin.harvard.edu wenqiang.chen.01@regionh.dk Mentorship My general statements: – Research lets me explore science and teach it. – Great scientists should also be great mentors. – Great