- wenqiang.chen@joslin.harvard.edu
- wenqiang.chen.01@regionh.dk
Publications
Here I will introduce what I have achieved in the past. But there are more ongoing works to be updated.
"There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance."
(1) Research papers
Single-cell investigations on disease stages
Most of the work here are coming from my first postdoc training in the Yi Zhang lab, where I was working on several projects in a highly collaborative environments:
- Project 1: reveal molecular heterogeneity underlying the brain reward systems (mPFC, NAc, and VTA)
- Project 2: characterize Set1da in schizophrenia pathogenesis.
- Project 3: characterize a dopamine neuron highly expressed protein in drug addiction (unpublished).
Some key figures:
- 2021, Nature Neuroscience, Figure 1, showing the major cell populations in the NAc
- 2022, Science Advances, Figure 6, showing the behavioral deficits in setd1a+/- mice (which I performed all the behavioral tests in this study)
- 2019, Nature Communications, Figure 1, showing the major cell populations in the PFC
- 2019, Nature Communications, Figure 6, showing how chronic cocaine IVSA alters transcriptional profiles in PFC cell types (which I contributed to the cocaine IVSA and provided the brain materials for scRNA-seq)
- 2022, Science Advances, Figure 1, showing Tac2-expressing MSN cells exhibited different responses to cocaine IVSA
Front-page images showing my co-first and co-author papers from the Ronald Kahn lab (02/2017 – 10/2019). All the papers are related to single-cell investigation of brain diseases (substance abuse and schizophrenia).
Role of Glial insulin signaling in AD pathogenesis
This is from my second postdoc training in the Ronald Kahn lab, where I mainly work on two glial cell types (astrocyte and microglia) and how they are involved in AD pathogenesis:
- Project 1 (iGIRKO/5xFAD): reveal astrocyte-specific insulin signaling in AD pathogenesis
- Project 2 (MGIRKO): reveal microglia-specific insulin signaling in health and in diseases
- Project 3 (MGIRKO/5xFAD): reveal microglia-specific insulin signaling in AD pathogenesis
- Project 4 (MG-DKO): reveal microglia-specifid insulin and IGF-1 signaling in health and in diseases
Front-page images showing my first author papers from the Ronald Kahn lab (10/2019 – ). All the papers are related to glial insulin signaling in AD pathogenesis.
Identification of dmPAGTac2 Neurons in aggression
In this collaborative project, where I serve as the co-corresponding author, we have provided evidence demonstrating the unique role of a molecularly distinct cell type, dmPAGTac2+ neurons, that regualte mouse aggressive behaviors:
- we have identified a molecular distinct cell type in the dmPAG that regulates aggression;
- we have provided the first characterization of dmPAGTac2 cells during aggression;
- we have revealed that dmPAGTac2 cells are not only necessary, but also sufficient for aggression;
- we have shown that the 5-HT systems in dmPAGTac2 cells respond to aggression.
Important figures showing the main key points of the dmPAGTac2 project (02/2018 – ). To support earlier sharing and open science, we have submitted the main manuscript to bioRxiv: https://www.biorxiv.org/content/10.1101/2023.10.19.562724v2.
Previous Graduate Training (M.Sc. & Ph.D.)
I was trained to be a behavioral neuroscientist, mainly working on using rodent models to study human brain disorders. During my previous graduate training, I was working on several exciting projects, including the following
- Project 1: establishing chlorpyrifos-induced rat model of mood disorders.
- Project 2: using agmatine to treat substance addition (morphone, etc)
- Project 3: revealing the role of GABAergic transmission during a critical period for spatial nagivation
Front-page images showing my first-author and co-author papers from my graduate trainings. All the papers are related to brain diseases.
Review papers
I was trained to be a behavioral neuroscientist, mainly working on using rodent models to study human brain disorders. During my previous graduate training, I was working on several exciting projects, including the following
- Project 1: establishing chlorpyrifos-induced rat model of mood disorders.
- Project 2: using agmatine to treat substance addition (morphone, etc)
- Project 3: revealing the role of GABAergic transmission during a critical period for spatial nagivation
Front-page images showing my first-author and coresponding-author review papers. All the papers are related to brain diseases and possible molecular mechanisms. Most of these review papers are commissioned during COVID-19.
Papers that are in Press and in Preparation
These are the papers in the making. Some of them are invited so in the process of writing (not mentioned here).
Chen W#, Kahn CR. (2024) Hormone of the Month: Insulin. Trends in Endocrinology & Metabolism. Invited mini-review (In Preparation) (#co-corresponding author) |
Chen W, Liu X, Munoz V, Kahn CR#. (2024) Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Ab and Neuroinflammatory Response Exacerbating Alzheimer-like Neuropathology. (Submitted, Cell Metabolism) |
© 2024 All Rights Reserved.
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